反应详情

温度

150 °C

A mixture of 3-butyryl-4-chloro-8-(2-methylthioethoxy)quinoline (400 mg, 1.23 mmol) and 2-isopropylaniline (1.0 g, 7.4 mmol) was heated to 150° C. for 30 min. The mixture was diluted with CHCl3 and extracted with 2N HCl. The organic phase was washed with a saturated sodium bicarbonate solution. The organic layer was dried over Na2SO4 and evaporated. The residue was chromatographed (SiO2 ; CH2Cl2 :MeOH 95:5) yielding 340 mg (80.5%) of the desired product.

1. extractionextracted with 2N HCl
2. washThe organic phase was washed with a saturated sodium bicarbonate solution
3. dry with materialThe organic layer was dried over Na2SO4
4. customevaporated
5. customThe residue was chromatographed (SiO2 ; CH2Cl2 :MeOH 95:5)