HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1419859Generated: November 3, 2026
2-Isopropylaniline → 3-Butyryl-4-(2-isopropylphenylamino)-8-(2-methylthioethoxy)quinoline
https://huagongshe.com/reaction/1419859
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Isopropylaniline | HCID 12561 | — |
| Reactant | 3-Butyryl-4-chloro-8-(2-methylthioethoxy)quinoline | HCID 54562429 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-Butyryl-4-(2-isopropylphenylamino)-8-(2-methylthioethoxy)quinoline | HCID 54495713 | 80.5% |
Reaction Steps
A mixture of 3-butyryl-4-chloro-8-(2-methylthioethoxy)quinoline (400 mg, 1.23 mmol) and 2-isopropylaniline (1.0 g, 7.4 mmol) was heated to 150° C. for 30 min. The mixture was diluted with CHCl3 and extracted with 2N HCl. The organic phase was washed with a saturated sodium bicarbonate solution. The organic layer was dried over Na2SO4 and evaporated. The residue was chromatographed (SiO2 ; CH2Cl2 :MeOH 95:5) yielding 340 mg (80.5%) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05889021 |
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| Source dataset | uspto-grants-1999_03 |
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| ORD ID | ord-4e84a958c98e4fb69770a2a3b0a5f35b |
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| Source note | uspto-grants-1999_03 |
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