Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | O-Toluidine | HCID 7242 | — |
| Reactant | HCID 54113854 | HCID 54113854 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 53940201 | HCID 53940201 | 62.2% |
Reaction Steps
A mixture of 3-propanoyl-4-chloro-8-(2-methylthioethoxy)quinoline (0.60 g, 1.9 mmol) and o-toluidine (0.25 g, 2.3 mmol) in acetonitrile was heated to 55° C. and stirred for 3.5 h. The solvent was evaporated and the residue was partitioned between methylene chloride and a 10% sodium carbonate solution. The organic layer was dried over sodium sulfate and evaporated. Chromatography (SiO2 ; CH2Cl2 :EtOAc 60:40) gave 0.45 g (61%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05889021 |
|---|
| Source dataset | uspto-grants-1999_03 |
|---|
| ORD ID | ord-827cdb1da10b4874b183a0f6c3c01f68 |
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| Source note | uspto-grants-1999_03 |
|---|
