反应详情

A mixture of 3-butyryl-4-chloro-8-(2-methylthioethoxy)quinoline (2.48 g, 6.63 mmol) and 4-hydroxy-2-methylaniline (1.06 g, 8.62 mmol) in acetonitrile (20 ml) was refluxed for 8 h. The reaction mixture was evaporated and the residue was chromatographed (SiO2 ; CH2Cl2 :MeOH 95:5) yielding 1.22 g (45%) of the desired product.

1. temperaturewas refluxed for 8 h
2. customThe reaction mixture was evaporated
3. customthe residue was chromatographed (SiO2 ; CH2Cl2 :MeOH 95:5)