HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-m-cresol → 3-Butyryl-4-(4-hydroxy-2-methylphenylamino)-8-(2-methylthioethoxy)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-m-cresol | HCID 17819 | — |
| Reactant | 3-Butyryl-4-chloro-8-(2-methylthioethoxy)quinoline | HCID 54562429 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-Butyryl-4-(4-hydroxy-2-methylphenylamino)-8-(2-methylthioethoxy)quinoline | HCID 54423280 | 45% |
Reaction Steps
A mixture of 3-butyryl-4-chloro-8-(2-methylthioethoxy)quinoline (2.48 g, 6.63 mmol) and 4-hydroxy-2-methylaniline (1.06 g, 8.62 mmol) in acetonitrile (20 ml) was refluxed for 8 h. The reaction mixture was evaporated and the residue was chromatographed (SiO2 ; CH2Cl2 :MeOH 95:5) yielding 1.22 g (45%) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05889021 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-3f76644b17324f4d8c13fc06d5d972e1 |
| Source note | uspto-grants-1999_03 |