2-(4-Methanesulfonamidophenoxy)ethyl bromide → N-(4-{2-[4-(4-Chloro-benzyl)-4-hydroxy-piperidin-1-yl]-ethoxy}-phenyl)-methanesulfonamide hydrochloride

HRID 1419894Notes

Reaction equation

HRID 1419894 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][C:7]2([OH:13])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.Br[CH2:17][CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][S:27]([CH3:30])(=[O:29])=[O:28])=[CH:22][CH:21]=1>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]2([OH:13])[CH2:8][CH2:9][N:10]([CH2:17][CH2:18][O:19][C:20]3[CH:21]=[CH:22][C:23]([NH:26][S:27]([CH3:30])(=[O:28])=[O:29])=[CH:24][CH:25]=3)[CH2:11][CH2:12]2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 111091562-(4-Methanesulfonamidophenoxy)ethyl bromideHCID 222454934-[(4-Chlorophenyl)methyl]piperidin-4-ol

Product 1

HCID 86754006N-(4-{2-[4-(4-Chloro-benzyl)-4-hydroxy-piperidin-1-yl]-ethoxy}-phenyl)-methanesulfonamide hydrochloride

Procedure

The title compound, m.p. 74°-77° C. and MS: m/e=439.4 (M+H+), was prepared from 4-(4-chloro-benzyl)-piperidin-4-ol and N-[4-(2-bromoethoxy)-phenyl]-methansulfonamide.

Sources & evidence

ORD record
ord-0075526a1feb41e3a6d1be8b8c5ed912
Source dataset
uspto-grants-1999_03
Patent number
US05889026

Reaction notes

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