4-[(4-Chlorophenyl)methyl]piperidin-4-ol → (RS)-4-(4-Chloro-benzyl)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-piperidin-4-ol hydrochloride

HRID 1419898Notes

Reaction equation

HRID 1419898 reaction equation
[O:1]1[CH2:3][CH:2]1[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[Cl:12][C:13]1[CH:26]=[CH:25][C:16]([CH2:17][C:18]2([OH:24])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)=[CH:15][CH:14]=1>>[ClH:12].[Cl:12][C:13]1[CH:14]=[CH:15][C:16]([CH2:17][C:18]2([OH:24])[CH2:19][CH2:20][N:21]([CH2:3][CH:2]([OH:1])[CH2:4][C:5]3[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=3)[CH2:22][CH2:23]2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 222454934-[(4-Chlorophenyl)methyl]piperidin-4-olHCID 53757927(RS)-4-Oxiranylmethyl-phenol

Product 1

HCID 70054529(RS)-4-(4-Chloro-benzyl)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-piperidin-4-ol hydrochloride

Procedure

The title compound, m.p. 172°-174° C. and MS: m/e=376.4 (M+H+), was prepared from (RS)-4-Oxiranylmethyl-phenol and 4-(4-Chloro-benzyl)-piperidin-4-ol.

Sources & evidence

ORD record
ord-17cbf61bb7764c35816114753b33f031
Source dataset
uspto-grants-1999_03
Patent number
US05889026

Reaction notes

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