4-(4-Methylbenzyl)-piperidin-4-ol → 1-[2-(4-Benzyloxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol

HRID 1419913Notes

Reaction equation

HRID 1419913 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1.[CH3:19][C:20]1[CH:33]=[CH:32][C:23]([CH2:24][C:25]2([OH:31])[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:22][CH:21]=1>>[CH2:12]([O:11][C:8]1[CH:9]=[CH:10][C:5]([O:4][CH2:3][CH2:2][N:28]2[CH2:29][CH2:30][C:25]([CH2:24][C:23]3[CH:22]=[CH:21][C:20]([CH3:19])=[CH:33][CH:32]=3)([OH:31])[CH2:26][CH2:27]2)=[CH:6][CH:7]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 105362424-(4-Methylbenzyl)-piperidin-4-olHCID 107570881-(Benzyloxy)-4-(2-bromoethoxy)benzene

Product 1

HCID 105044541-[2-(4-Benzyloxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol

Procedure

The title compound, MS: m/e=432.6 (M+H+), was prepared from 1-(2-bromoethoxy)-4-(benzyloxy)-benzene and 4-(4-methyl-benzyl)-piperidin-4-ol.

Sources & evidence

ORD record
ord-ec75162aaea94d549970ec39f60ab932
Source dataset
uspto-grants-1999_03
Patent number
US05889026

Reaction notes

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