4-[(4-Fluorophenyl)methyl]piperidin-4-ol → 1-[3-(4-Benzyloxy-phenoxy)-propyl]-4-(4-fluoro-benzyl)-piperidin-4-ol

HRID 1419916Notes

Reaction equation

HRID 1419916 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:8][CH:7]=1.[F:20][C:21]1[CH:34]=[CH:33][C:24]([CH2:25][C:26]2([OH:32])[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[CH:23][CH:22]=1>>[CH2:13]([O:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][N:29]2[CH2:28][CH2:27][C:26]([CH2:25][C:24]3[CH:23]=[CH:22][C:21]([F:20])=[CH:34][CH:33]=3)([OH:32])[CH2:31][CH2:30]2)=[CH:7][CH:8]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 104886244-[(4-Fluorophenyl)methyl]piperidin-4-olHCID 111100311-(Benzyloxy)-4-(3-bromopropoxy)benzene

Product 1

HCID 700469711-[3-(4-Benzyloxy-phenoxy)-propyl]-4-(4-fluoro-benzyl)-piperidin-4-ol

Procedure

The title compound, MS: m/e=450.5 (M+H+), was prepared from 1-(3-bromopropoxy)-4-(benzyloxy)-benzene and 4-(4-fluor-benzyl)-piperidin-4-ol.

Sources & evidence

ORD record
ord-9128b2a8c87b40b5830b526cbeb67668
Source dataset
uspto-grants-1999_03
Patent number
US05889026

Reaction notes

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