4-[(4-Chlorophenyl)methyl]piperidin-4-ol → N-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-[4-(4-chloro-benzyl)-4-hydroxy-piperidin-1-yl]-acetamide
Reaction equation
[C:1]([Si:5]([CH3:19])([CH3:18])[O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:17])[CH2:15]Cl)=[CH:9][CH:8]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:20][C:21]1[CH:34]=[CH:33][C:24]([CH2:25][C:26]2([OH:32])[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[CH:23][CH:22]=1>>[C:1]([Si:5]([CH3:19])([CH3:18])[O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:17])[CH2:15][N:29]2[CH2:28][CH2:27][C:26]([CH2:25][C:24]3[CH:23]=[CH:22][C:21]([Cl:20])=[CH:34][CH:33]=3)([OH:32])[CH2:31][CH2:30]2)=[CH:9][CH:8]=1)([CH3:4])([CH3:3])[CH3:2]Participants
3
Procedure
The title compound, m.p. 135°-136° C. and MS: m/e=489.4 (M+), was prepared from N-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-chloro-acetamide and 4-(4-Chloro-benzyl)-piperidin-4-ol.
Sources & evidence
- ORD record
- ord-f40c0cf6029b4d00ba5654f2fc684f3b
- Source dataset
- uspto-grants-1999_03
- Patent number
- US05889026
Reaction notes
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