HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[(4-Chlorophenyl)methyl]piperidin-4-ol → N-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-[4-(4-chloro-benzyl)-4-hydroxy-piperidin-1-yl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[(4-Chlorophenyl)methyl]piperidin-4-ol | HCID 22245493 | — |
| Reactant | N-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-chloro-acetamide | HCID 70046914 | — |
| Product | N-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-[4-(4-chloro-benzyl)-4-hydroxy-piperidin-1-yl]-acetamide | HCID 70045782 | — |
Reaction Steps
The title compound, m.p. 135°-136° C. and MS: m/e=489.4 (M+), was prepared from N-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-chloro-acetamide and 4-(4-Chloro-benzyl)-piperidin-4-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05889026 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-f40c0cf6029b4d00ba5654f2fc684f3b |
| Source note | uspto-grants-1999_03 |