4-(4-Methylbenzyl)-piperidin-4-ol → HCID 67598398, 화합물

HRID 1419944노트

반응식

HRID 1419944 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[CH2:5][CH:6]1[CH2:8][O:7]1.[CH3:14][C:15]1[CH:28]=[CH:27][C:18]([CH2:19][C:20]2([OH:26])[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[CH:17][CH:16]=1>CO>[F:1][C:2]1[CH:3]=[C:4]([CH2:5][CH:6]([OH:7])[CH2:8][N:23]2[CH2:24][CH2:25][C:20]([CH2:19][C:18]3[CH:17]=[CH:16][C:15]([CH3:14])=[CH:28][CH:27]=3)([OH:26])[CH2:21][CH2:22]2)[CH:9]=[CH:10][C:11]=1[O:12][CH3:13]

참가 물질

4

반응물 2

HCID 105362424-(4-Methylbenzyl)-piperidin-4-olHCID 53948112HCID 53948112, 화합물

생성물 1

HCID 67598398HCID 67598398, 화합물수율 81.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

(RS)-2-(3-Fluoro-4-methoxy-benzyl)-oxirane (0.48 g, 2.6 mmol) and 4-(4-methyl-benzyl)-piperidin-4-ol (0.65 g, 3.2 mmol) were dissolved in MeOH (3 ml) and stirred at room temperature for 16 hours. Solvent was evaporated and residue was chromatographed over silica gel (CH2Cl2MeOH 19:1) to provide (RS)-1-[3-(3-Fluoro-4-methoxy-phenyl)-2-hydroxy-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol (0.82 g, 81%) as a yellow oil MS: m/e=388.5 (M+H+).

후처리

  1. customSolvent was evaporated
  2. customresidue was chromatographed over silica gel (CH2Cl2MeOH 19:1)

출처 및 근거

ORD 기록
ord-62ac08ef39f741209d4410fe6b5358e0
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05889026

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