4-(4-Methylbenzyl)-piperidin-4-ol → HCID 67598398, compound

Participants

Reaction Steps

(RS)-2-(3-Fluoro-4-methoxy-benzyl)-oxirane (0.48 g, 2.6 mmol) and 4-(4-methyl-benzyl)-piperidin-4-ol (0.65 g, 3.2 mmol) were dissolved in MeOH (3 ml) and stirred at room temperature for 16 hours. Solvent was evaporated and residue was chromatographed over silica gel (CH2Cl2MeOH 19:1) to provide (RS)-1-[3-(3-Fluoro-4-methoxy-phenyl)-2-hydroxy-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol (0.82 g, 81%) as a yellow oil MS: m/e=388.5 (M+H+).

Provenance & Evidence