反应详情

To a stirred solution of 0.320 g of 2,3-dimethylbenzoyl chloride in 10 ml of methylene chloride is added 0.33 ml of triethylamine. After stirring for 15 minutes, 0.485 g of 10,11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine is added and stirring continued for 5 hours. The reaction mixture is washed with water, 1N HCl, NAHCO3, and brine. The reaction mixture is dried with Na2SO4, filtered and evaporated in vacuo to give a solid which is purified by flash chromatography using 1:1 ethyl acetate-hexane to give 0.39 g of solid, m.p. 168°-170° C.

1. stirringstirring
2. waitcontinued for 5 hours
3. washThe reaction mixture is washed with water, 1N HCl, NAHCO3, and brine
4. dry with materialThe reaction mixture is dried with Na2SO4
5. filtrationfiltered
6. customevaporated in vacuo
7. customto give a solid which
8. customis purified by flash chromatography