反应详情

A mixture of thioacetamide (15.0 g, 0.20 mol) and benzyl chloride (25.3 g, 0.20 mol) in chloroform (75 ml) was heated under reflux for 90 minutes (the thioacetamide required ~40 minutes to go into solution). The reaction mixture was then allowed to cool to room temperature and was then stood at 0° C. overnight, when colourless crystals formed as a layer on the surface. The product was filtered off, washed with cold 10% ether-chloroform and sucked dry to give the title compound (25.55 g) as colourless prisms. Mpt.=161°-163° C.

1. temperaturewas heated
2. customwhen colourless crystals formed as a layer on the surface
3. filtrationThe product was filtered off
4. washwashed with cold 10% ether-chloroform
5. customsucked dry