反应详情

(1-S-trans)-[3-(N,N-Dimethylamino)cyclopentyl]carbamic acid 1,1-dimethylethyl ester (0.537 g, 2.35 mmol) in 1,4-dioxan (4 ml) was treated with a saturated solution of hydrogen chloride in 1,4-dioxan (15 ml) and additional 1,4-dioxan (8 ml). After 50 minutes at 21° C., another portion of a saturated solution of hydrogen chloride in 1,4-dioxan (5 ml) was added, and after a further 2.5 h, the opaque solution was concentrated by evaporation to give the title compound as a beige solid, which was used without characterisation.

1. waitafter a further 2.5 h
2. concentrationthe opaque solution was concentrated by evaporation