HRID1420313

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID519314

2-chloro-9H-purine

C5H3ClN4

结构：CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(N[C@@H]4CCC[C@H]4O)nc32)[C@H](O)[C@@H]1O

HCID44352986

未命名化合物

PRODUCTS

生成物

结构：CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NC4CCCC4)nc32)[C@H](O)[C@@H]1O

HCID44352987

未命名化合物

PROCEDURE

实验过程

(1R-trans)-1-deoxy-1-[6-[(2,2-diphenylethyl)amino]-2-[(2-hydroxycyclopentyl)amino]-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide, from the 2-chloropurine (0.35 g) and (R)-(trans)-2aminocyclopentanol1 (1.0 g) at 130° C. for 10 h. The product was purified on silica eluting with ethyl acetate:methanol 19:1 and then on silica eluting with dichloromethane:methanol:0.880 ammonia (100:8:1). The product had m.p. 122° to 130° C. Analysis found C, 62.6, H, 6.2, N, 16.2%; C31H37N7O5.0.4H2O requires C, 62.6, H, 6.4, N, 16.5%.

WORKUP

后处理

customThe product was purified on silica eluting with ethyl acetate:methanol 19:1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2825f957eb5246f38d37a28d4307ee95
来源数据集: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05889178
来源说明: uspto-grants-1999_03

反应 SMILES

[C:1]1([CH:7]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[CH2:8][NH:9][C:10]2[N:18]=[C:17]([NH:19][C@@H:20]3[CH2:24][CH2:23][CH2:22][C@H:21]3O)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][N:14]3[C@@H:26]2[O:32][C@H:31]([C:33]([NH:35][CH2:36][CH3:37])=[O:34])[C@@H:29]([OH:30])[C@H:27]2[OH:28])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClC1N=C2C(NC=N2)=CN=1>>[CH:20]1([NH:19][C:17]2[N:16]=[C:15]3[C:11]([N:12]=[CH:13][N:14]3[C@@H:26]3[O:32][C@H:31]([C:33]([NH:35][CH2:36][CH3:37])=[O:34])[C@@H:29]([OH:30])[C@H:27]3[OH:28])=[C:10]([NH:9][CH2:8][CH:7]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[N:18]=2)[CH2:21][CH2:22][CH2:23][CH2:24]1