HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-7H-purine → (2-(Cyclopentylamino)-6-[(2,2-diphenylethyl)amino]-9H-purin-9-yl]-1-deoxy-N-ethyl-beta-D-ribofuranuronamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-7H-purine | HCID 519314 | — |
| Reactant | (1R-trans)-1-deoxy-1-[6-[(2,2-diphenylethyl)amino]-2-[(2-hydroxycyclopentyl)amino]-9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide | HCID 44352986 | — |
| Product | (2-(Cyclopentylamino)-6-[(2,2-diphenylethyl)amino]-9H-purin-9-yl]-1-deoxy-N-ethyl-beta-D-ribofuranuronamide | HCID 44352987 | — |
Reaction Steps
(1R-trans)-1-deoxy-1-[6-[(2,2-diphenylethyl)amino]-2-[(2-hydroxycyclopentyl)amino]-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide, from the 2-chloropurine (0.35 g) and (R)-(trans)-2aminocyclopentanol1 (1.0 g) at 130° C. for 10 h. The product was purified on silica eluting with ethyl acetate:methanol 19:1 and then on silica eluting with dichloromethane:methanol:0.880 ammonia (100:8:1). The product had m.p. 122° to 130° C. Analysis found C, 62.6, H, 6.2, N, 16.2%; C31H37N7O5.0.4H2O requires C, 62.6, H, 6.4, N, 16.5%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05889178 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-2825f957eb5246f38d37a28d4307ee95 |
| Source note | uspto-grants-1999_03 |