Cyclohexanecarbonyl chloride → L-Tryptophan

HRID 1420472Notes

Reaction equation

HRID 1420472 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=N)N.[CH:13]1(C(Cl)=O)[CH2:18][CH2:17]C[CH2:15][CH2:14]1>P([O-])([O-])([O-])=O.[Na+].[Na+].[Na+]>[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[C:17]2[C:7](=[CH:15][CH:14]=[CH:13][CH:18]=2)[NH:6][CH:5]=1

Participants

4

Reactant 2

HCID 75938Cyclohexanecarbonyl chlorideHCID 178418600HCID 178418600, compound

Product 1

HCID 6305L-Tryptophan

Reagents, catalysts & solvents 1

HCID 24243Trisodium PhosphateSolvent2×

Procedure

A stock solution of 9.1 mg/mL α-interferon in 20 mM sodium phosphate buffer at pH 7.2 was prepared. A stock solution of perturbant was prepared by dissolving 800 mg of perturbant (L-arginine acylated with cyclohexanoyl chloride) in 2 mL of 20 mM Sodium Phosphate buffer (pH7).

Workup

  1. customA stock solution of perturbant was prepared

Sources & evidence

ORD record
ord-98042e9638bf498e92c0442409445934
Source dataset
uspto-grants-2000_06
Patent number
US06071538

Reaction notes

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