Acetonitrile → HCID 57212035, compound

HRID 1420488Notes

Reaction equation

HRID 1420488 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([CH:9]([CH3:11])[CH3:10])[N:3]=1.C([O-])([O-])=O.[K+].[K+].Br.[CH3:19][N:20]1[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[N:22]=[CH:21]1.[C:29](#[N:31])[CH3:30]>>[NH2:1][C:2]1[N:3]=[C:4]([CH:9]([CH3:11])[CH3:10])[N:5]=[C:6]([NH:31][CH:29]([C:21]2[N:20]([CH3:19])[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[N:22]=2)[CH3:30])[N:7]=1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 11430Potassium CarbonateHCID 111165324-Chloro-6-isopropyl-1,3,5-triazin-2-amineHCID 18781878HCID 18781878, compound

Product 1

HCID 57212035HCID 57212035, compound

Procedure

2.6 g (0.015 mol) of 2-amino-4-chloro-6-isopropyl-1,3,5-triazine and 4.2 g (0.03 mol) of K2CO3 are introduced into 50 ml of acetonitrile. 3.8 g (0.015 mol) of 1-methylbenzimidazole hydrobromide are added to this solution, and the mixture is subsequently refluxed for 3 hours. Then, all solid constituents are filtered off with suction and the filtrate is evaporated on a rotary evaporator. The residue is purified by means of column chromatography (eluent: ethyl acetate). This gives 4.1 g (88% of theory) of 2-amino-4-isopropyl-6-[1-(1-methylbenzimidazol-2-yl)-1-ethylamino]-1,3,5-triazine.

Workup

  1. temperaturethe mixture is subsequently refluxed for 3 hours
  2. filtrationThen, all solid constituents are filtered off with suction
  3. customthe filtrate is evaporated on a rotary evaporator
  4. customThe residue is purified by means of column chromatography (eluent: ethyl acetate)

Sources & evidence

ORD record
ord-92d79fc52b48456ab6f1ec274dabf8ca
Source dataset
uspto-grants-2000_06
Patent number
US06071860

Reaction notes

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