反应详情

6-Iodo-1-phenylhexane (17.43 g, 0.061 mol), acetyl acetone(6.66 g, 0.067) and potassium carbonate (8.41 g, 0.061 mol) were dissolved in dry absolute ethanol (75 ml) nd the solution was retluxed for 18 hours. After cooling to room temperature the solution was filtered and evaporated under reduced pressure to an oil. This was partitioned between ethyl acetate (80 ml) and water (80 ml), and the organic layer was washed with brine, dried and evaporated to an orange oil (15.27 g). This was purified by flash chromatography on silica gel using petroleum ether/ethyl acetate to give 9-phenylnonan-2-one as a colourless oil (7.12 g, 54%).

1. filtrationwas filtered
2. customevaporated under reduced pressure to an oil
3. customThis was partitioned between ethyl acetate (80 ml) and water (80 ml)
4. washthe organic layer was washed with brine
5. customdried
6. customevaporated to an orange oil (15.27 g)
7. customThis was purified by flash chromatography on silica gel