Stannous chloride dihydrate → Methyl 3-Hydroxy-2-[(4-methoxybenzenesulfonyl)-(4-chloro-2-aminobenzyl)amino]propionate

HRID 1420602Notes

Reaction equation

HRID 1420602 reaction equation
[OH:1][CH2:2][CH:3]([N:8]([S:20]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)(=[O:22])=[O:21])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[N+:17]([O-])=O)[C:4]([O:6][CH3:7])=[O:5].O.O.Cl[Sn]Cl>CO>[OH:1][CH2:2][CH:3]([N:8]([S:20]([C:23]1[CH:24]=[CH:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=1)(=[O:22])=[O:21])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[NH2:17])[C:4]([O:6][CH3:7])=[O:5]

Participants

4

Reactant 2

HCID 61436Stannous chloride dihydrate2×HCID 18612795Methyl 3-Hydroxy-2-[(4-methoxybenzenesulfonyl)-(4-chloro-2-nitrobenzyl)amino]propionate

Product 1

HCID 18612723Methyl 3-Hydroxy-2-[(4-methoxybenzenesulfonyl)-(4-chloro-2-aminobenzyl)amino]propionate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 0.454 g (1 mmol) of methyl 3-hydroxy-2-[(4-methoxybenzenesulfonyl)-(4-chloro-2-nitrobenzyl)amino]propionate and 0.451 g (2 mmol) of SnCl2.2H2O in 12 ml of methanol was refluxed for 2 hours. An additional 0.451 g (2 mmol) of SnCl2.2H2O was added and the mixture refluxed for 2 hours.

Workup

  1. temperaturewas refluxed for 2 hours
  2. temperaturethe mixture refluxed for 2 hours

Sources & evidence

ORD record
ord-f4f70f69d03d4e0e95215c3ab145cc10
Source dataset
uspto-grants-2000_06
Patent number
US06071903

Reaction notes

Loading…