HCID 70133158, compound → HCID 70294273, compound

HRID 1420631Notes

Reaction equation

HRID 1420631 reaction equation
[ClH:1].[NH2:2][N:3]=[CH:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=O)=[CH:7][CH:6]=1.Cl.Cl.[CH3:16][C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[C:20]([O:27][CH2:28][C:29]3[C:30]([Cl:54])=[C:31]([S:36]([N:39]4[CH2:43][CH2:42][CH2:41][C@H:40]4[C:44]([NH:46][CH2:47][CH:48]4[CH2:53][CH2:52][NH:51][CH2:50][CH2:49]4)=[O:45])(=[O:38])=[O:37])[CH:32]=[CH:33][C:34]=3[Cl:35])[CH:21]=[CH:22][CH:23]=2)[N:18]=1>>[ClH:35].[ClH:1].[CH3:16][C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[C:20]([O:27][CH2:28][C:29]3[C:30]([Cl:54])=[C:31]([S:36]([N:39]4[CH2:43][CH2:42][CH2:41][C@H:40]4[C:44]([NH:46][CH2:47][CH:48]4[CH2:49][CH2:50][N:51]([C:9](=[O:11])[C:8]5[CH:7]=[CH:6][C:5]([CH:4]=[N:3][NH2:2])=[CH:13][CH:12]=5)[CH2:52][CH2:53]4)=[O:45])(=[O:38])=[O:37])[CH:32]=[CH:33][C:34]=3[Cl:35])[CH:21]=[CH:22][CH:23]=2)[N:18]=1

Participants

3

Reactant 2

HCID 70133158HCID 70133158, compoundHCID 70237930HCID 70237930, compound

Product 1

HCID 70294273HCID 70294273, compound

Procedure

By following a procedure analogous to Example 23, starting from 4-(aminoiminomethyl)benzoic acid hydrochloride and 1-[[3-[(2-methylquinolin-8-yl)oxymethyl]-2,4-dichlorophenyl]sulfonyl]-N-[(piperidin-4-yl)methyl]-2(S)-pyrrolidinecarboxamide dihydrochloride, the expected product is obtained in the form of a powdery white solid (yield=39%) after purification by means of reversed phase chromatography on RP18-grafted silica gel using a water/acetonitrile/hydrochloric acid mixture (63/32/1; v/v/v) as the eluent.

Sources & evidence

ORD record
ord-fe159598cfd1427bab16dd287de95b8c
Source dataset
uspto-grants-2000_06
Patent number
US06071917

Reaction notes

Loading…