HCID 70133158, compound → HCID 70294273, compound

Participants

Reaction Steps

By following a procedure analogous to Example 23, starting from 4-(aminoiminomethyl)benzoic acid hydrochloride and 1-[[3-[(2-methylquinolin-8-yl)oxymethyl]-2,4-dichlorophenyl]sulfonyl]-N-[(piperidin-4-yl)methyl]-2(S)-pyrrolidinecarboxamide dihydrochloride, the expected product is obtained in the form of a powdery white solid (yield=39%) after purification by means of reversed phase chromatography on RP18-grafted silica gel using a water/acetonitrile/hydrochloric acid mixture (63/32/1; v/v/v) as the eluent.

Provenance & Evidence