Potassium Carbonate → HCID 54250536, compound

HRID 1420673Notes

Reaction equation

HRID 1420673 reaction equation
[NH2:1][C@@H:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+].[I-].C([N+]1(C)[CH2:25][CH2:24][C:23](=[O:26])[CH2:22][CH2:21]1)C>C(O)C.O>[C@@H:2]1([N:1]2[CH2:25][CH2:24][C:23](=[O:26])[CH2:22][CH2:21]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 70000841-Aminoindane, (S)-HCID 110975681-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide

Product 1

HCID 54250536HCID 54250536, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

(S)-1-Aminoindane (37 mmol) was dissolved in ethanol (65 ml). Potassium carbonate (3.7 mmol) and 1-ethyl-1-methyl-4-oxo-piperidinium iodide (56 mmol) dissolved in water (30 ml) were added and the mixture was refluxed for 30 mil. Water was added, ethanol was removed in vacuo and the residue was extracted with ethyl acetate. Organic phases were pooled, dried with sodium sulfate and concentrated. Chromatography on silica gel (ethyl acetate) yielded the desired product as an oil. 7.1 g (90%) of (S)-1-indan-1-yl-piperidine-4-one, MS: m/e=216.4 (M+H+).

Workup

  1. additionwere added
  2. temperaturethe mixture was refluxed for 30 mil
  3. customethanol was removed in vacuo
  4. extractionthe residue was extracted with ethyl acetate
  5. dry with materialdried with sodium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-9a3779d10b21485eab72572827b0f44b
Source dataset
uspto-grants-2000_06
Patent number
US06071925

Reaction notes

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