反应详情

4-Bromophenyl propionate (115 g) (see Preparation 1) and aluminium chloride (150 g) were heated together at approximately 90° C. for 15 minutes. The solution became dark and hydrogen chloride gas was evolved. After cooling the black mass was carefully added to ice and a brown solid formed. The mixture was extracted with dichloromethane. The organic extract was separated, washed with brine, dried (anhydrous magnesium sulphate) and the solvent removed under reduced pressure to yield 1-(5-bromo-2-hydroxyphenyl)propane-1-one (110 g) as a yellow solid.

1. temperatureAfter cooling the black mass
2. additionwas carefully added to ice
3. customa brown solid formed
4. extractionThe mixture was extracted with dichloromethane
5. extractionThe organic extract
6. customwas separated
7. washwashed with brine
8. dry with materialdried (anhydrous magnesium sulphate)
9. customthe solvent removed under reduced pressure