1-(Benzyloxy)-4-(2,2,2-trifluoroethoxy)benzene → 4-(2,2,2-Trifluoroethoxy)phenol

HRID 1420813Notes

Reaction equation

HRID 1420813 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[F:18][C:17]([F:19])([F:20])[CH2:16][O:15][C:12]1[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=1

Participants

4

Reactant 1

HCID 227373741-(Benzyloxy)-4-(2,2,2-trifluoroethoxy)benzene

Product 1

HCID 130853484-(2,2,2-Trifluoroethoxy)phenol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1-benzyloxy-4-(2,2,2-trifluoroethoxy)benzene (Description 18, 5 g) and palladium (10% on carbon; 0.1 g) in methanol (50 ml) was hydrogenated at 50 psi for 12 h. The solution was filtered and the solvent removed in vacuo to give the title compound as a colourless solid m.p. 60-64° C.

Workup

  1. filtrationThe solution was filtered
  2. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-611e830e62fb4acda4fff896b86d76a9
Source dataset
uspto-grants-2000_06
Patent number
US06071927

Reaction notes

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