HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Benzyloxy)-4-(2,2,2-trifluoroethoxy)benzene → 4-(2,2,2-Trifluoroethoxy)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Benzyloxy)-4-(2,2,2-trifluoroethoxy)benzene | HCID 22737374 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(2,2,2-Trifluoroethoxy)phenol | HCID 13085348 | — |
Reaction Steps
A solution of 1-benzyloxy-4-(2,2,2-trifluoroethoxy)benzene (Description 18, 5 g) and palladium (10% on carbon; 0.1 g) in methanol (50 ml) was hydrogenated at 50 psi for 12 h. The solution was filtered and the solvent removed in vacuo to give the title compound as a colourless solid m.p. 60-64° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06071927 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-611e830e62fb4acda4fff896b86d76a9 |
| Source note | uspto-grants-2000_06 |