Hydrochloric Acid → L-Isoleucine--hydrogen chloride (1/1)

HRID 1421114Notes

Reaction equation

HRID 1421114 reaction equation
[ClH:1].[NH2:2][C@H:3]([C:8]([OH:10])=[O:9])[C@H:4]([CH2:6][CH3:7])[CH3:5]>O>[ClH:1].[NH2:2][C@H:3]([C:8]([OH:10])=[O:9])[C@H:4]([CH2:6][CH3:7])[CH3:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 6306L-Isoleucine

Product 1

HCID 16213693L-Isoleucine--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

a method of adding hydrochloric acid to an aqueous solution containing isoleucine and then repeatedly forming and precipitating crystals of isoleucine hydrochloride (J. Biologc. Chem., 118, 78 (1973)). However, there are the problems that the former method is very cumbersome in operation and difficult to separate isoleucine from valine and leucine, while the latter method results in lower yield because of the high solubility of crystals of isoleucine hydrochloride in water.

Workup

  1. customrepeatedly forming
  2. customprecipitating crystals of isoleucine hydrochloride (J. Biologc. Chem., 118, 78 (1973))
  3. customdifficult to separate isoleucine from valine and leucine
  4. customwhile the latter method results

Sources & evidence

ORD record
ord-7fcf9941f34245d5a309b1fe15fe1621
Source dataset
uspto-grants-2000_06
Patent number
US06072083

Reaction notes

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