Formaldehyde → HCID 11217378, compound
Reaction equation
[CH2:1]([C:3](=[CH:6][CH2:7][CH2:8][CH3:9])[CH:4]=O)[CH3:2].[CH2:10]=[O:11].CO.[OH-:14].[Na+]>COCCOCCOC>[CH2:8]([C:7]1[CH:10]([OH:14])[O:11][CH2:4][CH:3]([CH2:1][CH3:2])[CH:6]=1)[CH3:9]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
To a mixture of 776 g of 2-ethyl-2-hexenal (purity: 97.6%, 6.0 mol), 324 g (4.0 mol) of 37% formalin, and 550 g of methanol heated to 50° C. was added dropwise with stirring 64 g (0.4 mol) of a 25% aqueous solution of sodium hydroxide over one hour. After the dropping was completed, the mixture was further stirred at 50° C. for 3 hours. The reaction mixture was analyzed by gas chromatography (the internal standard method with diethylene glycol dimethyl ether as an internal standard), and the yields of 3,5-diethyl-5,6-dihydro-2H-2-pyranol based on the used formaldehyde and the consumed 2-ethyl-2-hexenal were found to be 26% and 30%, respectively.
Workup
- additionwas added dropwise
Sources & evidence
- ORD record
- ord-3cce890672ce4a4896189874dc29f151
- Source dataset
- uspto-grants-2000_06
- Patent number
- US06072089
Reaction notes
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