Ammonia → HCID 5327678, compound

HRID 1421141Notes

Reaction equation

HRID 1421141 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:30])[O:13][C:14](=O)[C:15]=2[C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([N+:25]([O-:27])=[O:26])[CH:23]=3)[N:18]([CH3:28])[CH:17]=2)=[CH:3]1.[NH3:31]>CN(C=O)C>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:30])[NH:31][C:14](=[O:13])[C:15]=2[C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([N+:25]([O-:27])=[O:26])[CH:23]=3)[N:18]([CH3:28])[CH:17]=2)=[CH:3]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 18780227HCID 18780227, compound

Product 1

HCID 5327678HCID 5327678, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
140 °C

Procedure

0.4 g of 3-(1-methyl-3-indolyl)-4-(1-methyl-5-nitro-3-indolyl)furan-2,5-dione was treated with 3 ml of DMF and 20 ml of 33% aqueous ammonia and heated at 140° C. for 3.5 hours. The cooled mixture was filtered and the residue was washed with water and dried to give 0.29 g of 3-(1-methyl-3-indolyl)-4-(1-methyl-5-nitro-3-indolyl)-1H-pyrrole-2,5-dione, m.p. 282°-284° C.

Workup

  1. filtrationThe cooled mixture was filtered
  2. washthe residue was washed with water
  3. customdried

Sources & evidence

ORD record
ord-1e5f8cc6a16a483fbc214f9ebc8f479d
Source dataset
uspto-grants-2000_06
Patent number
USRE036736

Reaction notes

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