Ammonia → HCID 5327667, compound

HRID 1421145Notes

Reaction equation

HRID 1421145 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=O)[O:13][C:14](=[O:21])[C:15]=2[C:16]2[CH:20]=[CH:19][S:18][CH:17]=2)=[CH:3]1.C[N:24](C=O)C.N>O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:13])[NH:24][C:14](=[O:21])[C:15]=2[C:16]2[CH:20]=[CH:19][S:18][CH:17]=2)=[CH:3]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 6228DimethylformamideHCID 14525671HCID 14525671, compound

Product 1

HCID 5327667HCID 5327667, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
140 °C

Procedure

0.28 g of 3-(1-methyl-3-indolyl)-4-(3-thienyl)furan-2,5-dione was treated with 10 ml of DMF and 40 ml of 33% aqueous ammonia. The mixture was heated at 140° C. for 4 hours. The cooled solution was poured into 150 ml of water and the resulting precipitate was filtered off and dried to give 0.15 g of 3-(1-methyl-3-indolyl)-4-(3-thienyl)-1H-pyrrole-2,5-dione, m.p. 211°-212° C.

Workup

  1. filtrationthe resulting precipitate was filtered off
  2. customdried

Sources & evidence

ORD record
ord-75651083223c4251a39522b0850a2ea5
Source dataset
uspto-grants-2000_06
Patent number
USRE036736

Reaction notes

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