Dimethylformamide → HCID 18780246, compound

HRID 1421147Notes

Reaction equation

HRID 1421147 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:23])[O:13][C:14](=O)[C:15]=2[C:16]2[N:17]([CH3:21])[CH:18]=[CH:19][CH:20]=2)=[CH:3]1.C[N:25](C=O)C>N>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:23])[NH:25][C:14](=[O:13])[C:15]=2[C:16]2[N:17]([CH3:21])[CH:18]=[CH:19][CH:20]=2)=[CH:3]1

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 18780285HCID 18780285, compound

Product 1

HCID 18780246HCID 18780246, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

A solution of 800 mg of 3-(1-methyl-3-indolyl)-4-(1-methyl-2-pyrrolyl)furan-2,5-dione in 6 ml of DMF and 50 ml of 33% aqueous ammonia was heated to 130° C. for 3 hours. The precipitate was filtered off and dried to yield 400 mg of 3-(1-methyl-3-indolyl)-4-(1-methyl-2-pyrrolyl)-1H-pyrrole-2,5-dione, m.p. 248°-250° C.

Workup

  1. filtrationThe precipitate was filtered off
  2. customdried

Sources & evidence

ORD record
ord-7ccdad8eb25945d6bdefb6246bc8affd
Source dataset
uspto-grants-2000_06
Patent number
USRE036736

Reaction notes

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