Ammonia → HCID 18780239, compound

HRID 1421164Notes

Reaction equation

HRID 1421164 reaction equation
[N:1]([CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([C:16]2[C:17](=[O:32])[NH:18][C:19](=[O:31])[C:20]=2[C:21]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[N:23]([CH3:30])[CH:22]=2)=[CH:8]1)=[C:2]=[S:3].C[N:34](C=O)C.N>C(O)C>[CH3:30][N:23]1[C:24]2[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:21]([C:20]2[C:19](=[O:31])[NH:18][C:17](=[O:32])[C:16]=2[C:9]2[C:10]3[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=3)[N:7]([CH2:6][CH2:5][CH2:4][NH:1][C:2]([NH2:34])=[S:3])[CH:8]=2)=[CH:22]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 6228DimethylformamideHCID 18780231HCID 18780231, compound

Product 1

HCID 18780239HCID 18780239, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A suspension of 100 mg of the product of Example 48 in 10 ml of ethanol was treated with 4 ml of DMF and then with 10 ml of a saturated solution of ammonia in ethanol. The mixture was left to stand at room temperature for 1 hour and the solvent was then evaporated. The residue was crystallized from ethanol to give 18 mg of 3-(1-methyl-3-indolyl)-4-[1-(3-thioureidopropyl)-3-indolyl]-1H-pyrrole-2,5-dione, m.p. 166°-168° C. (decomposition).

Workup

  1. waitThe mixture was left
  2. customthe solvent was then evaporated
  3. customThe residue was crystallized from ethanol

Sources & evidence

ORD record
ord-6b697e28983f45e1a800331c11f20705
Source dataset
uspto-grants-2000_06
Patent number
USRE036736

Reaction notes

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