反应详情

A solution of (R)-1(5-Acetoxyhexyl)-7-benzyl-3,8-dimethylxanthine (500 mg) in methanol (20 ml) was treated with 1 M hydrochloric acid in ether (2.5 ml) and stirred for 12 hours. After evaporation of volatiles under reduced pressure, the residue was dissolved in ethyl acetate (100 ml), washed with saturated sodium bicarbonate solution (30 ml), dried over anhydrous magnesium sulfate and concentrated. Yield=420 mg.

1. customAfter evaporation of volatiles under reduced pressure
2. dissolutionthe residue was dissolved in ethyl acetate (100 ml)
3. washwashed with saturated sodium bicarbonate solution (30 ml)
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated