Aniline → HCID 178448106, compound

HRID 1421271Notes

Reaction equation

HRID 1421271 reaction equation
[CH:1]([C@@H:4]1[CH2:9][CH2:8][C@H:7]([N:10]2[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[NH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CCCCC>[CH:1]([C@@H:4]1[CH2:9][CH2:8][C@H:7]([N:10]2[CH2:15][CH2:14][C:13](=[N:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:12][CH2:11]2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6115AnilineHCID 178448108HCID 178448108, compound

Product 1

HCID 178448106HCID 178448106, compound

Reagents, catalysts & solvents 1

HCID 8003PentaneSolvent

Procedure

cis-1-(4-Isopropyl-cyclohexyl)-piperidine-4-on (5.0 g, 23.4 mmol), aniline (3.3 g, 35.3 mmol) and molecular sieves (20 g, 4A) were stirred in 100 ml pentane at room temperature for 6 days. The molecular sieves was filtered off and the solvent was evaporated. The crude product was used without any further purification for the following step.

Workup

  1. filtrationThe molecular sieves was filtered off
  2. customthe solvent was evaporated
  3. customThe crude product was used without any further purification for the following step

Sources & evidence

ORD record
ord-3144cfbd527a460ca68e49764cadfe5e
Source dataset
uspto-grants-2000_06
Patent number
US06075034

Reaction notes

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