4-Fluoroaniline → HCID 178448107, compound

HRID 1421273Notes

Reaction equation

HRID 1421273 reaction equation
[CH:1]([C@@H:4]1[CH2:9][CH2:8][C@H:7]([N:10]2[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[F:17][C:18]1[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=1>CCCCC>[F:17][C:18]1[CH:24]=[CH:23][C:21]([N:22]=[C:13]2[CH2:14][CH2:15][N:10]([C@H:7]3[CH2:8][CH2:9][C@@H:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]3)[CH2:11][CH2:12]2)=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 97314-FluoroanilineHCID 178448108HCID 178448108, compound

Product 1

HCID 178448107HCID 178448107, compound

Reagents, catalysts & solvents 1

HCID 8003PentaneSolvent

Procedure

cis-1-(4-Isopropyl-cyclohexyl)-piperidine-4-on (5.0 g, 23.4 mmol), 4-fluoro aniline (3.3 g, 35.3 mmol) and molecular sieves (20 g, 4A) were stirred in 100 ml pentane at room temperature for 6 days. The molecular sieves was filtered off and the solvent was evaporated. The crude product was used without any further purification for the following step.

Workup

  1. filtrationThe molecular sieves was filtered off
  2. customthe solvent was evaporated
  3. customThe crude product was used without any further purification for the following step

Sources & evidence

ORD record
ord-049100d7eee149a2a1401959d30f5d11
Source dataset
uspto-grants-2000_06
Patent number
US06075034

Reaction notes

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