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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1421360Generated: October 31, 2026

P-Chloroacetophenone → Benzenemethanol, 4-chloro-alpha-methyl-

https://huagongshe.com/reaction/1421360

Reaction equation

Participants

RoleNameHCIDCharge
ReactantP-ChloroacetophenoneHCID 7467—
SolventIsopropanolHCID 3776—
ProductBenzenemethanol, 4-chloro-alpha-methyl-HCID 18825—

Reaction Conditions

Temperature120 °C

Reaction Steps

In a round-bottomed flask provided with magnetic stirrer and reflux condenser or in a 100 ml autoclave, 5.0 g (32.3 mmol) of p-chloroacetophenone, 45 g of isopropyl alcohol and 1.0 g of catalyst were heated under reflux or at 120° C. After the end of the reaction time, the reaction mixture was analyzed by gas chromatography and the yield was determined. The results are summarized in Table 3 below:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06075145
Source datasetuspto-grants-2000_06
ORD IDord-b64f969a67b546059b84684b38411f14
Source noteuspto-grants-2000_06