P-Chloroacetophenone → Benzenemethanol, 4-chloro-alpha-methyl-

HRID 1421360Notes

Reaction equation

HRID 1421360 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1>C(O)(C)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:10])[CH3:9])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 7467P-Chloroacetophenone

Product 1

HCID 18825Benzenemethanol, 4-chloro-alpha-methyl-

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
120 °C

Procedure

In a round-bottomed flask provided with magnetic stirrer and reflux condenser or in a 100 ml autoclave, 5.0 g (32.3 mmol) of p-chloroacetophenone, 45 g of isopropyl alcohol and 1.0 g of catalyst were heated under reflux or at 120° C. After the end of the reaction time, the reaction mixture was analyzed by gas chromatography and the yield was determined. The results are summarized in Table 3 below:

Workup

  1. customIn a round-bottomed flask provided with magnetic stirrer
  2. temperaturereflux condenser

Sources & evidence

ORD record
ord-b64f969a67b546059b84684b38411f14
Source dataset
uspto-grants-2000_06
Patent number
US06075145

Reaction notes

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