1-Phenylethanol → Acetophenone

HRID 1421362Notes

Reaction equation

HRID 1421362 reaction equation
[C:1]1([CH:7]([OH:9])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(=O)CCCCC1>C1(C)C=CC=CC=1>[C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)(=[O:9])[CH3:8]

Participants

4

Reactant 2

HCID 74091-PhenylethanolHCID 7967Cyclohexanone

Product 1

HCID 7410Acetophenone

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

5.0 g (40.9 mmol) of 1-phenylethanol, 15.0 g (153 mmol) of cyclohexanone and 1.0 g of catalyst from Example 9 in 30 g of toluene were heated at 70° C. under argon. After a reaction time of 10 hours, the reaction mixture was analyzed by gas chromatography. The yield of product was 94.2 percent.

Workup

  1. customAfter a reaction time of 10 hours

Sources & evidence

ORD record
ord-48f09b43e04d4a40b55c3d25141e90a7
Source dataset
uspto-grants-2000_06
Patent number
US06075145

Reaction notes

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