反应详情

(S)-4-[2-(Dimethyl-tert-butylsilyl)oxy-3-(dibenzylamino)propoxy]benzimidazole (1.27 g. 2.5 mmol) was dissolved in methanol (140 mL) and treated with an excess of ammonium formate (1.64 g, 25.0 mmol) followed by 10% palladium on carbon (410 mg). The resulting suspension was stirred at reflux for 1 hour. After cooling, the reaction mixture was filtered through a pad of celite. The filtrate was concentrated in vacuo to a brown oil (780 mg, 97%). NMR.

1. temperatureat reflux for 1 hour
2. temperatureAfter cooling
3. filtrationthe reaction mixture was filtered through a pad of celite
4. concentrationThe filtrate was concentrated in vacuo to a brown oil (780 mg, 97%)