Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 4-Ethyl-1H-indole-2,3-dione | HCID 13827082 | — |
| Product | HCID 13060519 | HCID 13060519 | 48% |
Reaction Steps
4-Ethyl isatin (3.1 g, 0.018 mol) was added to a mixture of conc. sulphuric acid (45 l) in acetic acid (14 ml). The suspension was warmed to 30° C., hydrogen peroxide 35% (2.2 ml) was added and after the addition the temperature was raised to 65° C. After being heated for 3 hours, the mixture was cooled and the precipitate filtered off, washed with water and dried to give the title compound (1.7 g), yield 48%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06077851 |
|---|
| Source dataset | uspto-grants-2000_06 |
|---|
| ORD ID | ord-e589acdf12da4950a6c5c16a467b9aa6 |
|---|
| Source note | uspto-grants-2000_06 |
|---|
