反应详情

温度

30 °C

4-Ethyl isatin (3.1 g, 0.018 mol) was added to a mixture of conc. sulphuric acid (45 l) in acetic acid (14 ml). The suspension was warmed to 30° C., hydrogen peroxide 35% (2.2 ml) was added and after the addition the temperature was raised to 65° C. After being heated for 3 hours, the mixture was cooled and the precipitate filtered off, washed with water and dried to give the title compound (1.7 g), yield 48%.

1. additionafter the addition the temperature
2. temperaturewas raised to 65° C
3. temperatureAfter being heated for 3 hours
4. temperaturethe mixture was cooled
5. filtrationthe precipitate filtered off
6. washwashed with water
7. customdried