反应详情

An ethanol solution (100 ml) of 4-chloro-4'-methylsulfinylmethyl benzophenone (5.8 g), ethyl carbazate (6.3 g) and pyridinium p-toluenesulfonate (0.1 g) was heated for 6 hours with refluxing. After cooling to a room temperature, the reaction mixture was poured into ice-water, and the precipitated crystals were collected by filtration, and washed successively with an aqueous sodium bicarbonate solution and water. After air-drying, 4-chloro-4'-methylsulfinylmethylbenzophenone ethoxycarbonylhydrazone (6.4 g) was obtained as an isomer mixture.

1. temperaturewith refluxing
2. filtrationthe precipitated crystals were collected by filtration
3. washwashed successively with an aqueous sodium bicarbonate solution and water
4. customAfter air-drying