Thiourea → S-(4-(4-chlorobenzoyl)benzyl)thiouronium bromide

HRID 1421546Notes

Reaction equation

HRID 1421546 reaction equation
[Br:1][CH2:2][C:3]1[CH:17]=[CH:16][C:6]([C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:4]=1.[NH2:18][C:19]([NH2:21])=[S:20]>CC(C)=O>[Br-:1].[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([C:7]([C:6]2[CH:16]=[CH:17][C:3]([CH2:2][S:20][C:19]([NH2:21])=[NH2+:18])=[CH:4][CH:5]=2)=[O:8])=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 98396514-(4-Chlorobenzoyl)benzyl bromide

Product 1

HCID 18779877S-(4-(4-chlorobenzoyl)benzyl)thiouronium bromideYield 85.4%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

An acetone solution (500 ml) of 4-bromomethyl-4'-chlorobenzophenone (31 g) and thiourea (10 g) was heated for 30 minutes with refluxing. The precipitated crystals were then collected by filtration and washed with acetone to obtain S-(4-(4-chlorobenzoyl)benzyl)thiouronium bromide (33 g).

Workup

  1. temperaturewith refluxing
  2. filtrationThe precipitated crystals were then collected by filtration
  3. washwashed with acetone

Sources & evidence

ORD record
ord-856fc1cebc144e7eb88891a8c8c5cbd4
Source dataset
uspto-grants-2000_06
Patent number
US06077866

Reaction notes

Loading…