1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 54342699, compound

HRID 1421548Notes

Reaction equation

HRID 1421548 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][S:15][CH2:16][CH2:17]Cl)=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.N12CCCN=C1CCCCC2>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][S:15][CH:16]=[CH2:17])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 53966775HCID 53966775, compound

Product 1

HCID 54342699HCID 54342699, compoundYield 98.8%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 4-chloro-4'-(2-chloroethylmercaptomethyl)benzophenone (4.9 g) and 1,8-diaza-bicyclo[5.4.0]undec-7-ene (4.3 g) in 100 ml of toluene was stirred for 3 hours at 80° C. After that, the mixture was washed with aqueous 2N hydrochloric acid solution and water, followed by drying over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain 4-chloro-4'-vinylmercaptomethylbenzophenone (4.3 g).

Workup

  1. washAfter that, the mixture was washed with aqueous 2N hydrochloric acid solution and water
  2. dry with materialby drying over anhydrous sodium sulfate
  3. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-c927f2840f344b7298a65d33d41e7cfc
Source dataset
uspto-grants-2000_06
Patent number
US06077866

Reaction notes

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