反应详情

To an acetic acid solution (30 ml) of 4-chloro-4'-methylmercaptomethylbenzophenone (8.3 g), aqueous 30% hydrogen peroxide solution (3.5 ml) was added, and the mixture was stirred for 2 hours while keeping at 10° C. To the reaction solution, water (200 ml) and toluene (200 ml) were added, and then the organic layer was separated, and washed successively with water, an aqueous sodium bicarbonate solution and an aqueous saturated sodium chloride solution, followed by drying over anhydrous magnesium sulfate. After distilling off the solvent, the crude product was purified by silicagel column chromatography (developing solvent: acetone:n-hexane=50:50) to obtain 4-chloro-4'-methylsulfinylmethylbenzophenone (5.3 g).

1. customwhile keeping at 10° C
2. customthe organic layer was separated
3. washwashed successively with water
4. dry with materialby drying over anhydrous magnesium sulfate
5. distillationAfter distilling off the solvent
6. customthe crude product was purified by silicagel column chromatography (developing solvent: acetone:n-hexane=50:50)