反应详情

Phosphorous trichloride (3.7 ml, 43 mmol) was added, dropwise, to a 10° C. slurry of N-neohexyl-L-aspartic acid (11.6 g, 53.4 mmol) in glacial acetic acid (50 ml). After addition was complete (0.5 hr), the resulting clear solution was stirred at room temperature overnight. The resulting solid precipitate was collected by vacuum filtration, washed with acetic acid and methylene chloride, then dried at 35-40° C. for 3 hours to give 3.62 g (69.8%) of pure N-neohexyl-L-aspartic anhydride.

1. customto a 10° C.
2. additionAfter addition
3. custom(0.5 hr)
4. filtrationThe resulting solid precipitate was collected by vacuum filtration
5. washwashed with acetic acid and methylene chloride
6. customdried at 35-40° C. for 3 hours