反应详情

A solution of N-benzyloxycarbonyl-N-neohexyl-L-aspartic acid, in acetic anhydride with a catalytic amount of phosphoric acid, is heated at reflux for 0.5 to 5 hours, is cooled to room temperature, and is concentrated under reduced pressure, with heating. The residual material is dissolved in water, then neutralized with aqueous sodium hydroxide. The resulting precipitate is collected by vacuum filtration, and is recrystallized to provide substantially pure N-neohexyl-L-aspartic anhydride.

1. temperatureat reflux for 0.5 to 5 hours
2. concentrationis concentrated under reduced pressure
3. temperaturewith heating
4. dissolutionThe residual material is dissolved in water
5. filtrationThe resulting precipitate is collected by vacuum filtration
6. customis recrystallized