Phosphoric Acid → N-neohexyl-L-aspartic anhydride

Participants

Reaction Steps

A solution of N-benzyloxycarbonyl-N-neohexyl-L-aspartic acid, in acetic anhydride with a catalytic amount of phosphoric acid, is heated at reflux for 0.5 to 5 hours, is cooled to room temperature, and is concentrated under reduced pressure, with heating. The residual material is dissolved in water, then neutralized with aqueous sodium hydroxide. The resulting precipitate is collected by vacuum filtration, and is recrystallized to provide substantially pure N-neohexyl-L-aspartic anhydride.

Provenance & Evidence